# veryyyyyyyyyyImp post.
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GENERAL # PATHOLOGY (keys in the end)

1. Leading cause of death due to poisoning?
2. CO poisoning inhibit which enzyme?
3. Name mitochondrial toxins ?
4. Most susceptible to hypoxia in nephron?
5. Irreversible damage to neuron occurs after ----- minutes of global hypoxia?
6. Most destructive free radicals?
7. Which vitamin is the best neutralizer of free radical?
8. Marker of intermediate filament degradation?
9. Mallory bodies are present in ?
10. Acetaminophen free radicals are formed in?
11. Wear and tear pigment?
12. Hemosedrin laden macrophages present in left sides heart failure are called?
13. What is called green bile ?
14. Disordered cell growth is calle ?
15. Examples of permanent cells?
16. Most common cause of caseous necrosis?
17. Programmed cell death is called?
18. Guardian of genome is?
19. Which is specific for pancreatitis?
20. Heterophagy is seen in which cell organelle?
21. Cerebral infarct is example of?
22. What is called red bile?
23. Extrinsic pathway in apoptosis require?
24. In lead poisoning lead deposits in?
25. Only endogenous pigment?
26. Which metaplasia occurs in brain?
27. Most susceptible zone in hypoxia of hepatocyte ?
28. Oxidase reaction produce which radicals?
29. Primary lysosomes are derived from ?
30. Lewy body seen in ?
31. Most common cause of tissues hypoxia?
32. Most common site for metastatic calcification? Kidney
33. Vitamin as an antioxidant?
34. Central organ in apoptosis?
35. Caspases are involved in which phenomenon?
36. Female had silicon breast implant which was then removed , wich cells would be
numerous ?
37. Omental necrosis is of which type?
38. Superimposed infection on necrosis is called ?
39. Metaplasia of surface epithelium most commonly causes by?
40. In our country the most common cause of cell injury is ?
41. Immediate affect after injury to a vessel is ?
41. Major circulating phagocyte?
42. Most important chemical mediator of inflammation?
43. Clearance of neutrophils in acute inflammation is by?
44. Neutrophil leucocytosis is caused by?
45. The hallmark of acute inflammation is increased ?
46. Acute phase reactants mostly synthesized in?
47. Most common cause of skin abscess?
48. Hall mark of chronic inflammation?
49. Kininogen converts into bradykinin due to?
50. Prostaglandin that helps in protection of gastrointestinal mucosa is??
51. Prostacyclin is produced by?
52. Fever in inflammation is caused by ?
53. ICAM and VCAM are responsible for ?
54. Most common cause of increases permeability?
55. Chemotaxis is a feature of ?
56. Most common cause of hyperkalemia?
57. Virchows triad?
58. Pulmonary thromboembolism originate from?
59. Best indicator of tissues hypoxia?
60. Most common cause of respiratory acidosis ?
61. Cushing triad?
62.most common manifestation of septic patient is ?
63. Most important distinguishing feature if hypo volumic and septic shock is ?
64. Last mediator of endo toxic shock ?
65. Death due to embolism after accident ?
66. Severe generalized Edema is called ?
67. Which vitamin involved in synthesis of collagen?
68. Keyloid is excess of which type of collagen?
69. Corticosteroid inc which wbc?
70. The hallmark of healing?
71. The element act as cofactor in collagen synthesis is?
72. Polyclonal gammopathy is sign of ?
73. The liver contain stem cells in?
74. Most important cells for wound contraction is?
75. Resistance to tension in main function of which collagen?
76. Liver regenerates in how many days?
77. Most common cause of impaired wound healing?
78. Cells increasing in number
Is called?
79. Grading of tumor is done by?
80. Sarcoma involves which origin?
81. Down syndrome is associated with which malignancy?
82. Most common metastatic cancer to bone?
83. Barrets esophagous associated with ?
84. Bcl-2 gene associated with which tumor ?
85. Ret gene associated with which tumor?
86. Li fraumani syndrome associated with which gene?
87. Colorectal carcinoma associated with which gene?
88. TRAP is tumor marker of?
89. S-100 tumor marker of?
90. Calcitonin tumor marker of?
91. Disease associated with asbestosis?
92. Vinyl chloride associated with which disease ?
93. ACTH like peptide are secreted by which tumor?
94. Name disease associated with Psamomma bodies?
95. Most common site of metastasis ?
96. Most common cancer related death?
97. Alkylating agents associated with which malignancy?
98. Polycythemia is associated with which carcinoma?
99. CA-125 tumor marker of ?
100. HTLV-1 virus associated cancer is?
101. Rb gene associated with which 2 tumors?
102. Dysplastic navus associated with which neoplasm?
103. Cachexia is mediated by?
104. c-kit gene associated tumor is?
105. Staging of tumor is done by?
106. Malignancy of skeletal muscle is called ?
107. Term carcinoma implies which origin?
108. Tumor involving all germs layers called?
109. DPC gene associated tumor?
110. Bombesin tumor marker of?
111. Poly cystic kidney disease is which Mendelian genetic disorder?
112. Known cause of congenital anomalies are ?
113. Most common autosomal recessive disorder is ?
114. First 4 weeks of life is called which period?
115. Which disease is commonly associated with down syndrome in younger age?
116. Mitochondrial DNA disorder is associated with ------ inheritance?
117. Barr body is attached to which part of cell?
118. Most common cause of neonatal death?
119. Cataract is caused by which infection during pregnancy?
120. XXY genotype is of ??
121. Best way to identify Turner syndrome?
122. Achondroplasia is associated with ??
123. Pt with primary amenorrhea, webbed neck , short stature.... What is Karyotype?
124. Allele is which type of gene ?
125. Triple marker for Down syndrome are??
126. Scanty Barr body ??
127. Most common type of Mendelian disorder is?
128. Most common X linked disorder is ?
129. Highest caloric value is of ?
130. Beriberi is due to which vit def?
131. Most common pathogen causing congenital infection is ?
132. Vit A used in treatment of?
133. The most common source of vit k is ?
134. Name essential fatty acids?
135. Tryptophan is used in synthesis of?
136. Ionization radiation damages which part of cell?
137. Most frequent type of cancer caused by radiation?
138. Nicotine patch is in treating of??
139. Most common drowning is ?
140. What is the most important factor determining daily energy expenditure ?
141. Most common cause of death in anorexia nervosa ?
142. First hematological sign in total body radiation?
143. Most common systemic complication of IV drug abuser?
144. Which element is use in diabetes?
145. Sepsis in burn patient is due to ?
146. Goat milk lacks in?
147. Gene which is defective in obesity?
148. Rat poisons contain which derivative?
149. Corn based diets are deficient in?
150. Which current os more dangerous?
151. What metabolite of nicotine used for screening?
152. Cofactor in conversion of dopamine to nor epinephrine?
153. Most common UV B light related cancer?
154. Vomiting in bulemia nervosa produces ----------- alkalosis?
155. What complication occurs in shaken baby syndrome?
156. Which bile acid is not reabsorbed in terminal and has role in producing colorectal long floor length evening selections in black
cancer?
157. 1st sign of vitamin A deficiency?
158. What is least sensitive to radiation?
159. Avidin in raw eggs bind with ?
160. Ulcer that may develop in burn tissue is ?
161. Bergers disease is strongly associated with ?
162. Pellagra is due to ----deficiency?
163. Name far soluble vitamins?
164. Sarcoma is derived of ?
165. Non neoplastic tissue in foreign origin?
166. ----- is a neoplastic component and ------ is non neoplastic component?
167. Benign tumors are enclosed by fibrinous capsule except?
168. Sarcomas spread through ------- and carcinomas through-------commonly?
169. Glioblastoma multiforme seeds in??
170. Most common cancer in children is ?
171. Most common type of mutation in cancer is ?
172. Most common anemia in cancer?
173. Most common pata neoplastic syndrome?
174. Carcinoma which invade tissues but dosen't metastasize?
175. Virus cause cancer because they have ??
176. Which of the following is the most radio sensitive phase of cell cycle?
177. Most radiosensitive tumor is ?
178. Tumor involving lymph vessels is called ?
179. Slowest growing thyroid tumor?
180. Radiation usually cause cancer after -----years?
KEYS
1. CO poisoning
2. Cytochrome oxidase.
3. Alcohol and salicylate
4. Proximal tubule
5. 5 min
6. Hydroxyl free radicals
7. Vit C
8. Ubiquitine
9. Alcoholic liver disease
10. Liver
11. Lipofuschin
12. Heart failure cells
13. Biliverdin
14. Dysplasia
15. Neurons, skeletal and cardiac muscle cells
16. TB
17. Apoptosis
18. P53
19. Lipase
20. Lysosomes
21. Liquifactve infarct
22. Bilirubin
23. TNF
24. Proximal renal tubule
25. Melanin
26. No metaplasia occurs in brain
27. Zone 3
28. Superoxide free radicals
29. Golgi apparatus
30. Idiopathic parkinson disease
31. Ischemia
32. Kidney
33. Vit E
34. Mitochondria
35. Apoptosis
36. Plasma cells
37. Fat necrosis
38. Wet gangrene
39. Chronic irritation.
40. Ischemia
41. Vasoconstriction
41. Neutrophil
42. Histamine
43. Apoptosis
44. Catecholamines , corticosteroids and lithium
45. Vascular permeability.
46. Liver
47. Staph aureus
48. Tissue destruction
49. Hageman factor
50. PGE2
51. Endothelial cells
52. IL1 and TNF-a
53. Leukocyte adhesion
54. Inflammation
55. Acute inflammation
56. Renal failure
57. Endothelial injury, abnormal blood flow and hypercoagubility
58. Femoral vein
59. Mixed venous O2
60. Anxiety
61. Inc bp, HTN, bradycardia
62. Hypotension
63. Temperature
64. IL6
65. Fat embolism
66. Anasarca
67. Vit c
68. Type 3
69. Neutrophils
70. Granulation tissue
71. Zinc
72. Chronic inflammation
73. Canal of hering
74. Myocibroblasts
75. Type 1 collagen
76. 10-14 days
77. Infections
78. Hyperplasia
79. Degree of cellular differentiation on histological appearance
80. Mesenchymal
81. ALL
82. Breast
83. Esophageal adenocarcinoma
84. Follicular lymphoma
85. MEN IIA and IIB
86. P53
87. APC
88. Hairy cell leukemia
89. Melanoma, astrocytoma
90. Thyroid medullary carcinoma
91. Mesothelioma and Bronchogenic carcinoma
92. Angiosarcoma
93. Small cell lung carcinoma
94. Papillary ca of thorid, serous papillary cystadebocarcinoma of ovary, meningioma,
malignant mesothelioma
95. Lymph nodes
96. Lung carcinoma
97. Leukemia
98. RCC
99. Ovarian carcinoma
100.Adult T cell leukemia/ lymphoma
101. Retinoblastoma and osteosarcoma
102. Malignant melanoma
103. TNF-a
104. Gastrointestinal stromal tumor (GIST)
105. Degree of localization/spread based on site and size
106. Rhabdomyosarcoma
107. Epithelial origin
108. Teratoma
109. Pancreatic cancer
110. Neuroblastoma, lung and gastric cancer
111. Autosomal dominant
112. Multifacrorial
113. Hemochromatosis
114. Neonatal period
115. Alzheimer's diseas
116. Maternal
117. Nuclear membrane
118. Prematurity
119. Rubella
120. Klinefelter syndrome
121. Karyotyping
122. Inc paternal age
123. XO
124. Non identical gene
125. Dec AFP, inc HCG , dec uterine estriol
126. Controversial .. I m with Turner syndrome
127. Autosomal recessive
128. fragile X syndrome
129. Fat
130. Vit B 1( thiamine)
131. CMV
132. Acne and acute premyelocytic leukemia
133. Colonic bacteria
134. Linoleic acid and linolenic acid
135. Niacin
136. DNA
137. Acute leukemia
138. Ulcerative colitis
139. Wet drowning
140. BMR
141. Ventricular arrhythmia
142. Lymphopenia
143. Hep B
144. Chromium
145. Pseudomonas aeroginosa
146. Folate and pyridoxine
147. Leptin
148. Coumarin
149. Tryptophan and niacin
150. AC current
151. Cotinine
152. Vit C
153. Basal cell carcinoma
154. Hypokalemic metabolic alkalosis
155. Retinal hemorrhage
156. Lithocholic acid
157. Night blindness
158. Bone
159. Biotin
160. Marjolin ulcer
161. Smoking
162. Niacin deficiency
163. ADEK
164. Connective tissue
165. Choristoma
166. Parenchyma , stroma
167. Uterine leiomyoma
168. Haematogenous ,, lymphatics
169. CSF
170. Acute lymphoblastic leukemia
171. Point mutation
172. Anemia of chronic disease
173. Hypercalcemia
174. Basal cell carcinoma
175. Oncogene
176. M phase
177. Lymph node
178. Cystic hygroma
179. Papillary carcinoma
180. 5-10 years